Hyakkimaru, a warrior on a quest to reclaim 48 of his body parts which were each taken by a demon, is joined by Dororo, a thief on a quest to avenge the death of her parents.
Takumi and his six-year-old son, Yuji, haven't come to terms with their wife and mother's death. One day, they meet a woman with an uncanny resemblance to her sheltering from the rain near their home.